Hamid Torkzadeh; Mohammad Irajian
Abstract
Introduction: This systematic review endeavors to amalgamate the available literature, assess the impact of CSS on pertinent outcomes in TKA, and offer insights into the potential advantages ...
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Introduction: This systematic review endeavors to amalgamate the available literature, assess the impact of CSS on pertinent outcomes in TKA, and offer insights into the potential advantages and constraints of CSS as a hemostatic agent.Material and Methods: Electronic databases, including PubMed, MEDLINE, Embase, and Cochrane Library, were explored from their inception until 2023. Various search terms, such as "carbazochrome sodium sulfonate," "hemostatic agents," "total knee arthroplasty," "knee replacement," "systematic review," and related expressions, were employed in combination. Additionally, the reference lists of relevant articles and reviews underwent manual screening to uncover additional studies.Results: The influence of CSS on postoperative bleeding constituted the focal point of assessment in all the encompassed studies. The majority of these studies reported a notable reduction in postoperative blood loss when CSS was employed compared to control groups. The aggregated analysis of the randomized controlled trials (RCTs) showcased a statistically significant decrease in postoperative bleeding among patients administered CSS (p<0.001).Conclusion: This systematic review implies that CSS may confer a positive impact in the context of total knee arthroplasty by diminishing postoperative bleeding and potentially enhancing pain and functional outcomes.
